The accrual of the CAIRO study was finished in December 2004 with 820 patients in 74 Dutch hospitals in 24 months. The results of an interim safety analysis were presented at ECCO 2005, ASCO GI 2006, and European Multidisciplinary Congress on Colorectal Cancer (EMCCC) 2006 in Berlin. This analysis resulted in the first publication of the CAIRO study in Oct 2006 in Annals of Oncology. The results on overall survival are expected at the end of this year and will be submitted for presentation to ASCO 2007. Principal investigator is C.J.A. Punt, and translational research is conducted in collaboration with J.H.J.M. van Krieken (UMC St Radboud).
A collaboration with several Dutch and international Investigators is on-going on clinical and translational research on data and material from the CAIRO studies. Collaborators include Prof.dr. C. Punt and Dr. I. Nagtegaal (Radboud University Nijmegen Medical Centre), Prof.dr. G. Meijer (VUmC Amsterdam), Dr. M. Koopman (UMC Utrecht), Prof.dr. H.J. Guchelaar and Prof.dr. R. Tollenaar (LUMC Leiden), Prof.dr. C. Uyl-de Groot (Erasmus MC Rotterdam), and Prof. Dr. M. Seymour and Prof.dr. Ph. Quirke (Leeds UK).